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Still another aspect of this invention is a method of maintaining useful levels of ranolazine in human plasma by administering a ranolazine containing dosage form only one or twice daily.

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The earliest predictable date that a generic version could become available is May 2019, when this patent expires.

The ideal forms of the apparatus for administration of the novel combinations for atrial fibrillation and other methods of the invention consist therefore of (1) either a syringe comprising 2 compartments containing the 2 active substances ready for use or (2) a kit containing two syringes ready for use.

Furthermore, in a recent study Gadicherla et al showed that in hearts exposed to global ischemia, the addition of ranolazine on reperfusion improved mitochondrial complex I activity, restored electron transfer through Fe-S clusters of complex I, and preserved supercomplex assembly and cardiolipin integrity.

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