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Fifteen trials met the inclusion criteria and are included in the review.

Concomitant rufinamide: initiate at a low dose and titrate; see full labeling.

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That is, the original problem that led to taking Depakote in the first place could return.

Caution should be exercised in patients with history of brain, liver, kidney problems, metabolic disease, blood disease, decrease in albumin, HIV infection, elderly, children, during pregnancy and breastfeeding.

Antiepileptic drugs are available by prescription only and are typically supplied for long-term use; thus, medical records were considered to be a good source of data for ascertainment of exposure.


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The FDA has issued a black box warning (the strictest warning category) for Depakote, as it can cause pancreatitis in children and adults and can result in liver failure.

It is better to discuss whatever questions you have with your doctor and follow his recommendations.

It is possible that some side effects of valproic acid may not have been reported.

It is not approved to treat bipolar conditions in children, although it has been known to be used in this off-label manner.

Your doctor may start you on higher doses (loading doses) early in your treatment to more quickly establish a blood level in the therapeutic range.

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The most common side effects with Depakote are headache, change in appetite, diarrhea, dizziness, drowsiness, hair loss, nausea, insomnia, weight changes.

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There is limited experience on long term effects on children.

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In the clinical trials, there was no evidence that higher doses led to greater efficacy.

A generic drug simply means that the drug is not made by the original manufacturer, the chemical is exactly the same.

Do not drive a car or operate machinery until you know how this medication affects you.

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These eight studies included 1565 pregnancy outcomes in which there was exposure to valproic acid monotherapy during the first trimester; in 118 of these outcomes there was a major congenital malformation as defined by EUROCAT.

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According to Wikipedia, (I take no personal credit for this answer) Valproic acid is used as a mood-stabilizing drug for Bipolar disorder, and in some cases, serious depression.

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Good luck, and remember-SCOTUS stated you decide what meds you take and how, not the pharmaceutical industry or even the FDA.

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In 2012, Abbot Laboratories pleaded guilty to federal charges for marketing Depakote as a drug to control agitation and aggression in elderly nursing home patients.

He also started developing tremors, which the doctor is not concerned about.

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Do not drive a car or operate dangerous machinery until you know how Depakote or Depakene affect you.

Do not start, stop, or change the dosage of any medicines without your doctor's approval.

It will probably take several weeks to see big enough changes in your symptoms to decide if valproate is the right medication for you.

This adverse reaction can also occur in patients using concomitant topiramate with valproate after starting topiramate treatment or after increasing the daily dose of topiramate (see Drug Interactions - Topiramate).

We examined relevant studies and conducted a meta-analysis to assess the effects of VPA on survival times and recurrence.

If the test you are talking about is an alpha-feta-protein AFP this is not a very accurate marker for all types of liver cancer.

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That's my opinion and my experience with this particular medication.

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The chief findings were a statistically significant increase in the incidence of subcutaneous fibrosarcomas in high dose male rats receiving valproic acid and a statistically significant dose-related trend for benign pulmonary adenomas in male mice receiving valproic acid.

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Obviously you are needing a moodstablizer to replace your Lithium for your overall mood, so you need to start medications separately.

Tell your doctor right away if you notice symptoms of liver problems (eg, a general feeling of discomfort, sluggishness, unusual tiredness or weakness, swelling of the face, loss of appetite, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes).

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Data for drugs prescribed in a hospital are not usually available at the physician level.

For example, a 50-year-old roofer would have a very difficult time working with epilepsy due to the risk of falling.

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Valproic acid is also used to treat mania (episodes of frenzied, abnormally excited mood) in people with bipolar disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods).

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